Le pubblicazioni dei componenti del gruppo di ricerca.
2022
Caccavo, Diego; Vecchia, Marica Della; Barba, Anna Angela; Lamberti, Gaetano
Simil-microfluidic ethanol injection mixer for the continuous synthesis production of liposomes: laminar vs turbulent regime Proceedings Article
In: CHISA - Prague (Czech Republic), 2022.
BibTeX | Tags: Drug Delivery Systems, Micro and Nano Vectors
@inproceedings{Caccavo2022,
title = {Simil-microfluidic ethanol injection mixer for the continuous synthesis production of liposomes: laminar vs turbulent regime},
author = {Diego Caccavo and Marica {Della Vecchia} and Anna Angela Barba and Gaetano Lamberti},
year = {2022},
date = {2022-08-23},
booktitle = {CHISA - Prague (Czech Republic)},
keywords = {Drug Delivery Systems, Micro and Nano Vectors},
pubstate = {published},
tppubtype = {inproceedings}
}
2017
Barba, Anna Angela; Cascone, Sara; Caccavo, Diego; Lamberti, Gaetano; Chiarappa, Gianluca; Abrami, Michela; Grassi, Gabriele; Grassi, Mario; Tomaiuolo, Giovanna; Guido, Stefano; Brucato, Valerio; Pavia, Francesco Carfì; Ghersi, Giulio; Carrubba, Vincenzo La; Abbiati, Roberto Andrea; Manca, Davide
Engineering approaches in siRNA delivery Journal Article
In: International Journal of Pharmaceutics, vol. 525, no 2, pp. 343–358, 2017.
Abstract | Links | BibTeX | Tags: Micro and Nano Vectors
@article{Barba2017,
title = {Engineering approaches in siRNA delivery},
author = {Anna Angela Barba and Sara Cascone and Diego Caccavo and Gaetano Lamberti and Gianluca Chiarappa and Michela Abrami and Gabriele Grassi and Mario Grassi and Giovanna Tomaiuolo and Stefano Guido and Valerio Brucato and Francesco {Carf\`{i} Pavia} and Giulio Ghersi and Vincenzo {La Carrubba} and Roberto Andrea Abbiati and Davide Manca},
url = {http://www.sciencedirect.com/science/article/pii/S0378517317301138},
doi = {10.1016/j.ijpharm.2017.02.032},
year = {2017},
date = {2017-06-20},
journal = {International Journal of Pharmaceutics},
volume = {525},
number = {2},
pages = {343\textendash358},
abstract = {siRNAs are very potent drug molecules, able to silence genes involved in pathologies development. siRNAs have virtually an unlimited therapeutic potential, particularly for the treatment of inflammatory diseases. However, their use in clinical practice is limited because of their unfavorable properties to interact and not to degrade in physiological environments. In particular they are large macromolecules, negatively charged, which undergo rapid degradation by plasmatic enzymes, are subject to fast renal clearance/hepatic sequestration, and can hardly cross cellular membranes. These aspects seriously impair siRNAs as therapeutics. As in all the other fields of science, siRNAs management can be advantaged by physical-mathematical descriptions (modeling) in order to clarify the involved phenomena from the preparative step of dosage systems to the description of drug-body interactions, which allows improving the design of delivery systems/processes/therapies. This review analyzes a few mathematical modeling approaches currently adopted to describe the siRNAs delivery, the main procedures in siRNAs vectors’ production processes and siRNAs vectors’ release from hydrogels, and the modeling of pharmacokinetics of siRNAs vectors. Furthermore, the use of physical models to study the siRNAs vectors’ fate in blood stream and in the tissues is presented. The general view depicts a framework maybe not yet usable in therapeutics, but with promising possibilities for forthcoming applications.},
keywords = {Micro and Nano Vectors},
pubstate = {published},
tppubtype = {article}
}
siRNAs are very potent drug molecules, able to silence genes involved in pathologies development. siRNAs have virtually an unlimited therapeutic potential, particularly for the treatment of inflammatory diseases. However, their use in clinical practice is limited because of their unfavorable properties to interact and not to degrade in physiological environments. In particular they are large macromolecules, negatively charged, which undergo rapid degradation by plasmatic enzymes, are subject to fast renal clearance/hepatic sequestration, and can hardly cross cellular membranes. These aspects seriously impair siRNAs as therapeutics. As in all the other fields of science, siRNAs management can be advantaged by physical-mathematical descriptions (modeling) in order to clarify the involved phenomena from the preparative step of dosage systems to the description of drug-body interactions, which allows improving the design of delivery systems/processes/therapies. This review analyzes a few mathematical modeling approaches currently adopted to describe the siRNAs delivery, the main procedures in siRNAs vectors’ production processes and siRNAs vectors’ release from hydrogels, and the modeling of pharmacokinetics of siRNAs vectors. Furthermore, the use of physical models to study the siRNAs vectors’ fate in blood stream and in the tissues is presented. The general view depicts a framework maybe not yet usable in therapeutics, but with promising possibilities for forthcoming applications.