The publications of the members of the research group.
2009
Barba, Anna Angela; Dalmoro, Annalisa; Santis, Felice De; Lamberti, Gaetano
Synthesis and characterization of P(MMA-AA) copolymers for targeted oral drug delivery Journal Article
In: Polymer Bulletin, vol. 62, no. 5, pp. 679–688, 2009, ISSN: 0170-0839.
Abstract | Links | BibTeX | Tags: drug delivery, Enteric coating, P(MMA-AA)
@article{Barba2009d,
title = {Synthesis and characterization of P(MMA-AA) copolymers for targeted oral drug delivery},
author = { Anna Angela Barba and Annalisa Dalmoro and Felice De Santis and Gaetano Lamberti},
url = {http://dx.doi.org/10.1007/s00289-009-0040-4},
doi = {10.1007/s00289-009-0040-4},
issn = {0170-0839},
year = {2009},
date = {2009-01-01},
journal = {Polymer Bulletin},
volume = {62},
number = {5},
pages = {679--688},
publisher = {Springer-Verlag},
abstract = {This paper describes the development of pH-sensitive poly(methyl methacrylate-acrylic acid) copolymers for the enteric coating of pharmaceutical products for oral administration. To obtain the dissolution at the desired pH level, different pH-sensitive polymers are available on the market. Usually, for each desired dissolution pH, an ad hoc polymer is designed. Thus, different dissolution pH values could ask for completely different polymers. Instead, the materials proposed in this work are copolymers of the same two monomers, and the different dissolution pH was obtained by changing the volume fraction of the hydrophobic methyl methacrylate monomer to the hydrophilic acrylic acid monomer. Increasing the volumetric percentage of methyl methacrylate causes the polymer to dissolve at increasing pH, until the dissolution does not take place at all, and it is replaced by a slow swelling phenomenon. The copolymers obtained were characterized by differential scanning calorimetry, in order to evaluate their glass transition temperature, and these latter were related to %MMA. The molecular weights of the pure polymers (PAA, PMMA) were measured by intrinsic viscosity, to further validate the glass transition temperatures observed. The dissolution of the copolymers was carefully tested in buffer solutions for a dense set of pH values. A linear relationship between dissolution pH and volumetric percentage of methyl methacrylate was obtained from these measurements. As a result, for any physiological compartment, the copolymer which dissolves at the pH of interest can be easily synthesized.},
keywords = {drug delivery, Enteric coating, P(MMA-AA)},
pubstate = {published},
tppubtype = {article}
}
This paper describes the development of pH-sensitive poly(methyl methacrylate-acrylic acid) copolymers for the enteric coating of pharmaceutical products for oral administration. To obtain the dissolution at the desired pH level, different pH-sensitive polymers are available on the market. Usually, for each desired dissolution pH, an ad hoc polymer is designed. Thus, different dissolution pH values could ask for completely different polymers. Instead, the materials proposed in this work are copolymers of the same two monomers, and the different dissolution pH was obtained by changing the volume fraction of the hydrophobic methyl methacrylate monomer to the hydrophilic acrylic acid monomer. Increasing the volumetric percentage of methyl methacrylate causes the polymer to dissolve at increasing pH, until the dissolution does not take place at all, and it is replaced by a slow swelling phenomenon. The copolymers obtained were characterized by differential scanning calorimetry, in order to evaluate their glass transition temperature, and these latter were related to %MMA. The molecular weights of the pure polymers (PAA, PMMA) were measured by intrinsic viscosity, to further validate the glass transition temperatures observed. The dissolution of the copolymers was carefully tested in buffer solutions for a dense set of pH values. A linear relationship between dissolution pH and volumetric percentage of methyl methacrylate was obtained from these measurements. As a result, for any physiological compartment, the copolymer which dissolves at the pH of interest can be easily synthesized.